The discovery of vitamins was one of the great discoveries of the 19th century. In the 1897, Ackerman found only polished white rice in Java to develop beriberi, and untreated brown rice could cure the disease. It was found that the substance that could be treated with beriberi could be extracted with water or alcohol, which was called "water-soluble B". The 1906 proved that food contains "ancillary factors" other than protein, lipids, carbohydrates, inorganic salts and water, which are small but necessary for animal growth. The 1911 Casimir Feng identified a substance that can fight beriberi in brown rice, which is similar in nature to the distribution of food, and is mostly supplemented by enzymes. Some supply must balance each other, such as vitamin B1, B2 and PP, otherwise can affect physiological function. Vitamin B complexes include: Pantothenate, niacin, biotin, folic acid, vitamin B1 (thiamine), vitamin B2 (riboflavin), Praziquantel (vitamin B6) and cyanide cobalt (vitamin B12). Choline, inositol, P-aminophenol, carnitine, and lipoic acid were also included in B-complex bodies.
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